Semaglutide vs Tirzepatide, Cagrilintide, and Retatrutide: Mechanisms & Research Insights Full article: Pharmacotherapy for Obesity: Recent Updates Comparing the Big 3, Semaglutide, Tirzepatide and Retatrutide : r Mounjaro In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results Dual and Triple Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data Current Obesity Reports Springer Nature Link