Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Figure 1 from Oral melanotic macule a case report. Semantic Scholar Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update