Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.