Paracetamol (acetaminophen) poisoning: The early years Prescott 2024 British Journal of Clinical Pharmacology Wiley Online Library Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona File:Paracetamol metabolism.svg Wikimedia Commons